Polymyalgia rheumatica is an inflammatory disorder manifested principally by stiffness of the neck, shoulder girdle, and pelvic girdle; giant-cell (or temporal) arteritis affects the cranial branches of arteries arising from the aortic arch. The two conditions are believed to be linked and may occur together. Giant-cell arteritis is a serious disorder that can cause blindness as a result of ischemia of the optic nerve or retina. Both disorders respond to corticosteroid therapy. This comprehensive article reviews the clinical manifestations, pathophysiology, and treatment of these disorders.
Polymyalgia rheumatica and giant-cell arteritis / Salvarani, Carlo; Cantini, Fabrizio; Boiardi, Luigi; Hunder, Gene G.. - In: THE NEW ENGLAND JOURNAL OF MEDICINE. - ISSN 0028-4793. - 347:(2002), pp. 261-271. [10.1056/NEJMra011913]
Polymyalgia rheumatica and giant-cell arteritis
SALVARANI, CARLO;
2002
Abstract
Polymyalgia rheumatica is an inflammatory disorder manifested principally by stiffness of the neck, shoulder girdle, and pelvic girdle; giant-cell (or temporal) arteritis affects the cranial branches of arteries arising from the aortic arch. The two conditions are believed to be linked and may occur together. Giant-cell arteritis is a serious disorder that can cause blindness as a result of ischemia of the optic nerve or retina. Both disorders respond to corticosteroid therapy. This comprehensive article reviews the clinical manifestations, pathophysiology, and treatment of these disorders.
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