Polymyalgia rheumatica (PMR) is an inflammatory disease that typically affects elderly people. Its clinical hallmark is the severity of pain in the shoulder and pelvic girdle. Mild to moderate synovitis and/or bursitis of the joints involved has been described. Neuropeptides are involved in nociception and modulation of inflammatory reaction. To evaluate whether neuropeptides have a role in PMR pathophysiology, we studied the expression of substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and somatostatin (SOM) in shoulder synovial tissues of PMR patients.

Synovial expression of vasoactive intestinal peptide in polymyalgia rheumatica / Pulsatelli, L; Dolzani, P; Silvestri, T; De Giorgio, R; Salvarani, Carlo; Macchioni, P; Frizziero, L; Meliconi, R.. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 24:(2006), pp. 562-566.

Synovial expression of vasoactive intestinal peptide in polymyalgia rheumatica

SALVARANI, CARLO;
2006

Abstract

Polymyalgia rheumatica (PMR) is an inflammatory disease that typically affects elderly people. Its clinical hallmark is the severity of pain in the shoulder and pelvic girdle. Mild to moderate synovitis and/or bursitis of the joints involved has been described. Neuropeptides are involved in nociception and modulation of inflammatory reaction. To evaluate whether neuropeptides have a role in PMR pathophysiology, we studied the expression of substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and somatostatin (SOM) in shoulder synovial tissues of PMR patients.
2006
24
562
566
Synovial expression of vasoactive intestinal peptide in polymyalgia rheumatica / Pulsatelli, L; Dolzani, P; Silvestri, T; De Giorgio, R; Salvarani, Carlo; Macchioni, P; Frizziero, L; Meliconi, R.. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 24:(2006), pp. 562-566.
Pulsatelli, L; Dolzani, P; Silvestri, T; De Giorgio, R; Salvarani, Carlo; Macchioni, P; Frizziero, L; Meliconi, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1082537
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