The pharmacokinetics of flecainide has been studied in 12 patients with ventricular arrhythmias, both after single administration and during chronic treatment. Both the half-life and the AUC were significantly increased during chronic treatment. This suggests that the kinetics of flecainide might be non-linear also in patients with normal kidney and liver function. The increase in plasma flecainide levels during chronic treatment could not be predicted, so close monitoring of its plasma levels is advisable.
FLECAINIDE - EVIDENCE OF NONLINEAR KINETICS / Boriani, Giuseppe; Strocchi, E; Capucci, A; Calliva, R; Frabetti, L; Ambrosioni, E; Magnani, B.. - In: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. - ISSN 0031-6970. - 41:1(1991), pp. 57-59. [10.1007/BF00280107]
FLECAINIDE - EVIDENCE OF NONLINEAR KINETICS
BORIANI, Giuseppe;
1991
Abstract
The pharmacokinetics of flecainide has been studied in 12 patients with ventricular arrhythmias, both after single administration and during chronic treatment. Both the half-life and the AUC were significantly increased during chronic treatment. This suggests that the kinetics of flecainide might be non-linear also in patients with normal kidney and liver function. The increase in plasma flecainide levels during chronic treatment could not be predicted, so close monitoring of its plasma levels is advisable.
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