Objectives: Vascular endothelialgrowthfactor(VEGF)isapotentinduceroftumorangiogenesisandrepresentsthekeyelementinthe pathogenesis ofclearcellrenalcellcarcinoma(ccRCC).TheaimofthisstudywastoinvestigatetheuseoftumorVEGFexpressionasa parameter toidentifytumorstageandprognosticallydifferentpatientgroups. Methods andmaterials: We retrospectivelycollectedclinicaldataof137patientstreatedwithpartialorradicalnephrectomyatour institutions fororgan-confined, locallyadvanced,andmetastaticccRCCsbetween1984and2013.TumorcellVEGFimmunohistochemical expression wascomparedwithpathologicalandclinicalfeaturesincludingage,sex,tumorstage,andFuhrmangrade.ComparisonofVEGF expression levelsbetweentumorstageswasperformedviaKruskal-Wallisnonparametrictest.SurvivalanalysiswasconductedviaKaplan- Meier product-limitmethod,andMantel-Haenszellog-ranktestwasemployedtocomparesurvivalamonggroups. Results: Medianageatdiagnosiswas61years(range:33–85y).TumorstagewaspT1N0M0in67patients(49%),pT2N0M0in5(4%),and pT3N0M0in25(18%),while40patients(29%)hadmetastatictumorsat diagnosis.FuhrmannucleargradewasG1in22patients(16%),G2in60 (44%),G3in33(24%),G4in13patients(9%),andunknownin9patients. TumorVEGFwasdifferentiallyexpressedamongdifferentstages (P o 0.001)andinlow(G1–2)andhigh(G3–4) Fuhrmangradetumors(P o 0.001).Nosignificantdifferenceswerefoundwhenstratifyingbysex (P ¼ 0.06)orage(P ¼ 0.29).Medianoverallsurvival(OS)frompartialorradicalnephrectomywas161months(range:1–366).Weobserveda significantly longerOSinpatientswithlow(o25%)vs.high(425%)VEGFexpressionlevels(medianOS206vs.65mo, P o 0.001). Conclusions: OurdatashowthattumorcellVEGFexpressionissignificantly associatedwithtumorstageandFuhrmangradeandis able topredictpatientoutcome,suggestingapotentialuseofthisparameter inidentifyingprognosticallydifferentpatientswithccRCC.

Tumor VEGF expression correlates with tumor stage and identifies prognostically different groups in patients with clear cell renal cell carcinoma / Minardi, D.; Santoni, M.; Lucarini, G.; Mazzucchelli, R.; Burattini, L.; Conti, A.; Bianconi, M.; Scartozzi, M.; Milanese, G.; Di Primio, R.; Montironi, R.; Cascinu, Stefano; Muzzonigro, G.. - In: UROLOGIC ONCOLOGY. - ISSN 1078-1439. - ELETTRONICO. - 33:3(2015), pp. 1-7. [10.1016/j.urolonc.2014.06.014]

Tumor VEGF expression correlates with tumor stage and identifies prognostically different groups in patients with clear cell renal cell carcinoma

CASCINU, Stefano;
2015

Abstract

Objectives: Vascular endothelialgrowthfactor(VEGF)isapotentinduceroftumorangiogenesisandrepresentsthekeyelementinthe pathogenesis ofclearcellrenalcellcarcinoma(ccRCC).TheaimofthisstudywastoinvestigatetheuseoftumorVEGFexpressionasa parameter toidentifytumorstageandprognosticallydifferentpatientgroups. Methods andmaterials: We retrospectivelycollectedclinicaldataof137patientstreatedwithpartialorradicalnephrectomyatour institutions fororgan-confined, locallyadvanced,andmetastaticccRCCsbetween1984and2013.TumorcellVEGFimmunohistochemical expression wascomparedwithpathologicalandclinicalfeaturesincludingage,sex,tumorstage,andFuhrmangrade.ComparisonofVEGF expression levelsbetweentumorstageswasperformedviaKruskal-Wallisnonparametrictest.SurvivalanalysiswasconductedviaKaplan- Meier product-limitmethod,andMantel-Haenszellog-ranktestwasemployedtocomparesurvivalamonggroups. Results: Medianageatdiagnosiswas61years(range:33–85y).TumorstagewaspT1N0M0in67patients(49%),pT2N0M0in5(4%),and pT3N0M0in25(18%),while40patients(29%)hadmetastatictumorsat diagnosis.FuhrmannucleargradewasG1in22patients(16%),G2in60 (44%),G3in33(24%),G4in13patients(9%),andunknownin9patients. TumorVEGFwasdifferentiallyexpressedamongdifferentstages (P o 0.001)andinlow(G1–2)andhigh(G3–4) Fuhrmangradetumors(P o 0.001).Nosignificantdifferenceswerefoundwhenstratifyingbysex (P ¼ 0.06)orage(P ¼ 0.29).Medianoverallsurvival(OS)frompartialorradicalnephrectomywas161months(range:1–366).Weobserveda significantly longerOSinpatientswithlow(o25%)vs.high(425%)VEGFexpressionlevels(medianOS206vs.65mo, P o 0.001). Conclusions: OurdatashowthattumorcellVEGFexpressionissignificantly associatedwithtumorstageandFuhrmangradeandis able topredictpatientoutcome,suggestingapotentialuseofthisparameter inidentifyingprognosticallydifferentpatientswithccRCC.
2015
26-lug-2014
33
3
1
7
Tumor VEGF expression correlates with tumor stage and identifies prognostically different groups in patients with clear cell renal cell carcinoma / Minardi, D.; Santoni, M.; Lucarini, G.; Mazzucchelli, R.; Burattini, L.; Conti, A.; Bianconi, M.; Scartozzi, M.; Milanese, G.; Di Primio, R.; Montironi, R.; Cascinu, Stefano; Muzzonigro, G.. - In: UROLOGIC ONCOLOGY. - ISSN 1078-1439. - ELETTRONICO. - 33:3(2015), pp. 1-7. [10.1016/j.urolonc.2014.06.014]
Minardi, D.; Santoni, M.; Lucarini, G.; Mazzucchelli, R.; Burattini, L.; Conti, A.; Bianconi, M.; Scartozzi, M.; Milanese, G.; Di Primio, R.; Montironi, R.; Cascinu, Stefano; Muzzonigro, G.
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