No data are present in the literature regarding chemokine (CXC motif) ligand (CXCL)9 and CXCL11 circulating levels in cryoglobulinemia associated with hepatitis C (MC+HCV), in presence/absence of autoimmune thyroiditis (AT). Serum CXCL9 and CXCL11 have been measured in 38 MC+HCV patients without AT (MCo), 38 MC+HCV patients with AT (MC+AT), and in matched controls without (control 1) or with thyroiditis (control 2). Serum CXCL9 and CXCL11 were significantly higher: in control 2 than control 1 (p<0.05); in MCo than control 1 and control 2 (p<0.001, for both); in MC+AT than control 1 and control 2 (p<0.0001, for both), and than MCo (p=0.01, for both). Our study demonstrates markedly high serum levels of CXCL9 and CXCL11 in patients with MC+HCV compared to healthy controls; in MC+HCV patients increased CXCL9 and CXCL11 levels were significantly associated with the presence of AT. Moreover, a strong relation between circulating CXCL9 and CXCL11 in MC+HCV has been shown.

PATIENTS WITH MIXED CRYOGLOBULINEMIA AND HCV INFECTION, IN PRESENCE OR ABSENCE OF AUTOIMMUNE THYROIDITIS, HAVE HIGH SERUM LEVELS OF (CXC MOTIF) LIGAND (CXCL)9 AND CXCL11 CHEMOKINES / Antonelli, A; Fallahi, P; Ferrari, Silvia Martina; Frascerra, S; Corrado, A; Colaci, Michele; Manfredi, Andreina Teresa; Maccheroni, M; Sansonno, D; Zignego, Al; Centanni, M; Ferri, Clodoveo. - In: EUROPEAN JOURNAL OF INFLAMMATION. - ISSN 1721-727X. - 10:(2012), pp. 437-445. [10.1177/1721727X1201000319]

PATIENTS WITH MIXED CRYOGLOBULINEMIA AND HCV INFECTION, IN PRESENCE OR ABSENCE OF AUTOIMMUNE THYROIDITIS, HAVE HIGH SERUM LEVELS OF (CXC MOTIF) LIGAND (CXCL)9 AND CXCL11 CHEMOKINES

FERRARI, Silvia Martina;COLACI, Michele;MANFREDI, Andreina Teresa;FERRI, Clodoveo
2012

Abstract

No data are present in the literature regarding chemokine (CXC motif) ligand (CXCL)9 and CXCL11 circulating levels in cryoglobulinemia associated with hepatitis C (MC+HCV), in presence/absence of autoimmune thyroiditis (AT). Serum CXCL9 and CXCL11 have been measured in 38 MC+HCV patients without AT (MCo), 38 MC+HCV patients with AT (MC+AT), and in matched controls without (control 1) or with thyroiditis (control 2). Serum CXCL9 and CXCL11 were significantly higher: in control 2 than control 1 (p<0.05); in MCo than control 1 and control 2 (p<0.001, for both); in MC+AT than control 1 and control 2 (p<0.0001, for both), and than MCo (p=0.01, for both). Our study demonstrates markedly high serum levels of CXCL9 and CXCL11 in patients with MC+HCV compared to healthy controls; in MC+HCV patients increased CXCL9 and CXCL11 levels were significantly associated with the presence of AT. Moreover, a strong relation between circulating CXCL9 and CXCL11 in MC+HCV has been shown.
2012
10
437
445
PATIENTS WITH MIXED CRYOGLOBULINEMIA AND HCV INFECTION, IN PRESENCE OR ABSENCE OF AUTOIMMUNE THYROIDITIS, HAVE HIGH SERUM LEVELS OF (CXC MOTIF) LIGAND (CXCL)9 AND CXCL11 CHEMOKINES / Antonelli, A; Fallahi, P; Ferrari, Silvia Martina; Frascerra, S; Corrado, A; Colaci, Michele; Manfredi, Andreina Teresa; Maccheroni, M; Sansonno, D; Zignego, Al; Centanni, M; Ferri, Clodoveo. - In: EUROPEAN JOURNAL OF INFLAMMATION. - ISSN 1721-727X. - 10:(2012), pp. 437-445. [10.1177/1721727X1201000319]
Antonelli, A; Fallahi, P; Ferrari, Silvia Martina; Frascerra, S; Corrado, A; Colaci, Michele; Manfredi, Andreina Teresa; Maccheroni, M; Sansonno, D; Zignego, Al; Centanni, M; Ferri, Clodoveo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1075488
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