Human dental pulp represents a suitable alternative source of stem cells for the purpose of cell-based therapies in regenerative medicine, because it is relatively easy to obtain it, using low invasive procedures. This study characterized and compared two subpopulations of adult stem cells derived from human dental pulp (hDPSCs). Human DPSCs, formerly immune-selected for STRO-1 and c-Kit, were separated for negativity and positivity to CD34 expression respectively, and evaluated for cell proliferation, stemness maintenance, cell senescence and multipotency.
Human dental pulp stem cells (hDPSCs): isolation, enrichment and comparative differentiation of two sub-populations / Pisciotta, Alessandra; Carnevale, Gianluca; Meloni, Simona; Riccio, Massimo; De Biasi, Sara; Gibellini, Lara; Ferrari, Adriano; Bruzzesi, Giacomo; De Pol, Anto. - In: BMC DEVELOPMENTAL BIOLOGY. - ISSN 1471-213X. - ELETTRONICO. - 15:(2015), pp. 1-16. [10.1186/s12861-015-0065-x]
Human dental pulp stem cells (hDPSCs): isolation, enrichment and comparative differentiation of two sub-populations
PISCIOTTA, ALESSANDRA;CARNEVALE, Gianluca
;RICCIO, Massimo;DE BIASI, SARA;GIBELLINI, Lara;FERRARI, Adriano;BRUZZESI, GIACOMO;DE POL, Anto
2015
Abstract
Human dental pulp represents a suitable alternative source of stem cells for the purpose of cell-based therapies in regenerative medicine, because it is relatively easy to obtain it, using low invasive procedures. This study characterized and compared two subpopulations of adult stem cells derived from human dental pulp (hDPSCs). Human DPSCs, formerly immune-selected for STRO-1 and c-Kit, were separated for negativity and positivity to CD34 expression respectively, and evaluated for cell proliferation, stemness maintenance, cell senescence and multipotency.
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