BACKGROUND:As yet, no population-based prospective studies have been conducted to investigate the incidence and clinical outcome of glioblastoma (GBM) or the diffusion and impact of the current standard therapeutic approach in newly diagnosed patients younger than aged 70 years. METHODS: Data on all new cases of primary brain tumors observed from January 1, 2009, to December 31, 2010, in adults residing within the Emilia-Romagna region were recorded in a prospective registry in the Project of Emilia Romagna on Neuro-Oncology (PERNO). Based on the data from this registry, a prospective evaluation was made of the treatment efficacy and outcome in GBM patients. RESULTS: Two hundred sixty-seven GBM patients (median age, 64 y; range, 29-84 y) were enrolled. The median overall survival (OS) was 10.7 months (95% CI, 9.2-12.4). The 139 patients ≤aged 70 years who were given standard temozolomide treatment concomitant with and adjuvant to radiotherapy had a median OS of 16.4 months (95% CI, 14.0-18.5). With multivariate analysis, OS correlated significantly with KPS (HR = 0.458; 95% CI, 0.248-0.847; P = .0127), MGMT methylation status (HR = 0.612; 95% CI, 0.388-0.966; P = .0350), and treatment received in a high versus low-volume center (HR = 0.56; 95% CI, 0.328-0.986; P = .0446). CONCLUSIONS: The median OS following standard temozolomide treatment concurrent with and adjuvant to radiotherapy given to (72.8% of) patients aged ≤70 years is consistent with findings reported from randomized phase III trials. The volume and expertise of the treatment center should be further investigated as a prognostic factor.

Pattern of care and effectiveness of treatment for glioblastoma patients in the real world: Results from a prospective population-based registry. Could survival differ in a high-volume center? / Brandes, Alba A; Franceschi, Enrico; Ermani, Mario; Tosoni, Alicia; Albani, Fiorenzo; Depenni, Roberta; Faedi, Marina; Pisanello, Anna; Crisi, Girolamo; Urbini, Benedetta; Dazzi, Claudio; Cavanna, Luigi; Mucciarini, Claudia; Pasini, Giuseppe; Bartolini, Stefania; Marucci, Gianluca; Morandi, Luca; Zunarelli, Elena; Cerasoli, Serenella; Gardini, Giorgio; Lanza, Giovanni; Silini, Enrico Maria; Cavuto, Silvio; Baruzzi, Agostino; Baruzzi, A; Albani, F; Calbucci, F; D'Alessandro, R; Michelucci, R; Brandes, A; Eusebi, V; Ceruti, S; Fainardi, E; Tamarozzi, R; Emiliani, E; Cavallo, M; Franceschi, E; Tosoni, A; Cavallo, M; Fiorica, F; Valentini, A; Depenni, R; Mucciarini, C; Crisi, G; Sasso, E; Biasini, C; Cavanna, L; Guidetti, D; Marcello, N; Pisanello, A; Cremonini, A. M; Guiducci, G; de Pasqua, S; Testoni, S; Agati, R; Ambrosetto, G; Bacci, A; Baldin, E; Baldrati, A; Barbieri, E; Bartolini, S; Bellavista, E; Bisulli, F; Bonora, E; Bunkheila, F; Carelli, V; Crisci, M; Dall'Occa, P; de Biase, D; Ferro, S; Franceschi, C; Frezza, G; Grasso, V; Leonardi, M; Marucci, G; Mazzocchi, V; Morandi, L; Mostacci, B; Palandri, G; Pasini, E; Pastore Trossello, M; Pession, A; Ragazzi, M; Riguzzi, P; Rinaldi, R; Rizzi, S; Romeo, G; Spagnolli, F; Tinuper, P; Trocino, C; Cerasoli, S; Dall'Agata, M; Faedi, M; Frattarelli, M; Gentili, G; Giovannini, A; Iorio, P; Pasquini, U; Galletti, G; Guidi, C; Neri, W; Patuelli, A; Strumia, S; Casmiro, M; Gamboni, A; Rasi, F; Cruciani, G; Cenni, P; Dazzi, C; Guidi, Ar; Zumaglini, F; Amadori, A; Pasini, G; Pasquinelli, M; Pasquini, E; Polselli, A; Ravasio, A; Viti, B; Sintini, M; Ariatti, A; Bertolini, F; Bigliardi, G; Carpeggiani, P; Cavalleri, F; Meletti, Stefano; Nichelli, Paolo Frigio; Pettorelli, E; Pinna, G; Zunarelli, E; Artioli, F; Bernardini, I; Costa, M; Greco, G; Guerzoni, R; Stucchi, C; Iaccarino, C; Rizzi, R; Zuccoli, G; Api, P; Cartei, F; Fallica, E; Granieri, E; Latini, F; Lelli, G; Monetti, C; Ramponi, V; Saletti, A; Schivalocchi, R; Seraceni, S; Tola, M. R; Urbini, B; Giorgi, C; Montanari, E; Cerasti, D; Crafa, P; Dascola, I; Florindo, I; Mazza, S; Servadei, F; Silini, Em; Torelli, P; Immovilli, P; Morelli, N; Vanzo, C.. - In: NEURO ONCOLOGY PRACTICE. - ISSN 2054-2585. - STAMPA. - 1:(2014), pp. 166-171. [10.1093/nop/npu021]

Pattern of care and effectiveness of treatment for glioblastoma patients in the real world: Results from a prospective population-based registry. Could survival differ in a high-volume center?

Ragazzi, M;MELETTI, Stefano;NICHELLI, Paolo Frigio;Iaccarino, C;
2014

Abstract

BACKGROUND:As yet, no population-based prospective studies have been conducted to investigate the incidence and clinical outcome of glioblastoma (GBM) or the diffusion and impact of the current standard therapeutic approach in newly diagnosed patients younger than aged 70 years. METHODS: Data on all new cases of primary brain tumors observed from January 1, 2009, to December 31, 2010, in adults residing within the Emilia-Romagna region were recorded in a prospective registry in the Project of Emilia Romagna on Neuro-Oncology (PERNO). Based on the data from this registry, a prospective evaluation was made of the treatment efficacy and outcome in GBM patients. RESULTS: Two hundred sixty-seven GBM patients (median age, 64 y; range, 29-84 y) were enrolled. The median overall survival (OS) was 10.7 months (95% CI, 9.2-12.4). The 139 patients ≤aged 70 years who were given standard temozolomide treatment concomitant with and adjuvant to radiotherapy had a median OS of 16.4 months (95% CI, 14.0-18.5). With multivariate analysis, OS correlated significantly with KPS (HR = 0.458; 95% CI, 0.248-0.847; P = .0127), MGMT methylation status (HR = 0.612; 95% CI, 0.388-0.966; P = .0350), and treatment received in a high versus low-volume center (HR = 0.56; 95% CI, 0.328-0.986; P = .0446). CONCLUSIONS: The median OS following standard temozolomide treatment concurrent with and adjuvant to radiotherapy given to (72.8% of) patients aged ≤70 years is consistent with findings reported from randomized phase III trials. The volume and expertise of the treatment center should be further investigated as a prognostic factor.
2014
1
166
171
Pattern of care and effectiveness of treatment for glioblastoma patients in the real world: Results from a prospective population-based registry. Could survival differ in a high-volume center? / Brandes, Alba A; Franceschi, Enrico; Ermani, Mario; Tosoni, Alicia; Albani, Fiorenzo; Depenni, Roberta; Faedi, Marina; Pisanello, Anna; Crisi, Girolamo; Urbini, Benedetta; Dazzi, Claudio; Cavanna, Luigi; Mucciarini, Claudia; Pasini, Giuseppe; Bartolini, Stefania; Marucci, Gianluca; Morandi, Luca; Zunarelli, Elena; Cerasoli, Serenella; Gardini, Giorgio; Lanza, Giovanni; Silini, Enrico Maria; Cavuto, Silvio; Baruzzi, Agostino; Baruzzi, A; Albani, F; Calbucci, F; D'Alessandro, R; Michelucci, R; Brandes, A; Eusebi, V; Ceruti, S; Fainardi, E; Tamarozzi, R; Emiliani, E; Cavallo, M; Franceschi, E; Tosoni, A; Cavallo, M; Fiorica, F; Valentini, A; Depenni, R; Mucciarini, C; Crisi, G; Sasso, E; Biasini, C; Cavanna, L; Guidetti, D; Marcello, N; Pisanello, A; Cremonini, A. M; Guiducci, G; de Pasqua, S; Testoni, S; Agati, R; Ambrosetto, G; Bacci, A; Baldin, E; Baldrati, A; Barbieri, E; Bartolini, S; Bellavista, E; Bisulli, F; Bonora, E; Bunkheila, F; Carelli, V; Crisci, M; Dall'Occa, P; de Biase, D; Ferro, S; Franceschi, C; Frezza, G; Grasso, V; Leonardi, M; Marucci, G; Mazzocchi, V; Morandi, L; Mostacci, B; Palandri, G; Pasini, E; Pastore Trossello, M; Pession, A; Ragazzi, M; Riguzzi, P; Rinaldi, R; Rizzi, S; Romeo, G; Spagnolli, F; Tinuper, P; Trocino, C; Cerasoli, S; Dall'Agata, M; Faedi, M; Frattarelli, M; Gentili, G; Giovannini, A; Iorio, P; Pasquini, U; Galletti, G; Guidi, C; Neri, W; Patuelli, A; Strumia, S; Casmiro, M; Gamboni, A; Rasi, F; Cruciani, G; Cenni, P; Dazzi, C; Guidi, Ar; Zumaglini, F; Amadori, A; Pasini, G; Pasquinelli, M; Pasquini, E; Polselli, A; Ravasio, A; Viti, B; Sintini, M; Ariatti, A; Bertolini, F; Bigliardi, G; Carpeggiani, P; Cavalleri, F; Meletti, Stefano; Nichelli, Paolo Frigio; Pettorelli, E; Pinna, G; Zunarelli, E; Artioli, F; Bernardini, I; Costa, M; Greco, G; Guerzoni, R; Stucchi, C; Iaccarino, C; Rizzi, R; Zuccoli, G; Api, P; Cartei, F; Fallica, E; Granieri, E; Latini, F; Lelli, G; Monetti, C; Ramponi, V; Saletti, A; Schivalocchi, R; Seraceni, S; Tola, M. R; Urbini, B; Giorgi, C; Montanari, E; Cerasti, D; Crafa, P; Dascola, I; Florindo, I; Mazza, S; Servadei, F; Silini, Em; Torelli, P; Immovilli, P; Morelli, N; Vanzo, C.. - In: NEURO ONCOLOGY PRACTICE. - ISSN 2054-2585. - STAMPA. - 1:(2014), pp. 166-171. [10.1093/nop/npu021]
Brandes, Alba A; Franceschi, Enrico; Ermani, Mario; Tosoni, Alicia; Albani, Fiorenzo; Depenni, Roberta; Faedi, Marina; Pisanello, Anna; Crisi, Girolamo; Urbini, Benedetta; Dazzi, Claudio; Cavanna, Luigi; Mucciarini, Claudia; Pasini, Giuseppe; Bartolini, Stefania; Marucci, Gianluca; Morandi, Luca; Zunarelli, Elena; Cerasoli, Serenella; Gardini, Giorgio; Lanza, Giovanni; Silini, Enrico Maria; Cavuto, Silvio; Baruzzi, Agostino; Baruzzi, A; Albani, F; Calbucci, F; D'Alessandro, R; Michelucci, R; Brandes, A; Eusebi, V; Ceruti, S; Fainardi, E; Tamarozzi, R; Emiliani, E; Cavallo, M; Franceschi, E; Tosoni, A; Cavallo, M; Fiorica, F; Valentini, A; Depenni, R; Mucciarini, C; Crisi, G; Sasso, E; Biasini, C; Cavanna, L; Guidetti, D; Marcello, N; Pisanello, A; Cremonini, A. M; Guiducci, G; de Pasqua, S; Testoni, S; Agati, R; Ambrosetto, G; Bacci, A; Baldin, E; Baldrati, A; Barbieri, E; Bartolini, S; Bellavista, E; Bisulli, F; Bonora, E; Bunkheila, F; Carelli, V; Crisci, M; Dall'Occa, P; de Biase, D; Ferro, S; Franceschi, C; Frezza, G; Grasso, V; Leonardi, M; Marucci, G; Mazzocchi, V; Morandi, L; Mostacci, B; Palandri, G; Pasini, E; Pastore Trossello, M; Pession, A; Ragazzi, M; Riguzzi, P; Rinaldi, R; Rizzi, S; Romeo, G; Spagnolli, F; Tinuper, P; Trocino, C; Cerasoli, S; Dall'Agata, M; Faedi, M; Frattarelli, M; Gentili, G; Giovannini, A; Iorio, P; Pasquini, U; Galletti, G; Guidi, C; Neri, W; Patuelli, A; Strumia, S; Casmiro, M; Gamboni, A; Rasi, F; Cruciani, G; Cenni, P; Dazzi, C; Guidi, Ar; Zumaglini, F; Amadori, A; Pasini, G; Pasquinelli, M; Pasquini, E; Polselli, A; Ravasio, A; Viti, B; Sintini, M; Ariatti, A; Bertolini, F; Bigliardi, G; Carpeggiani, P; Cavalleri, F; Meletti, Stefano; Nichelli, Paolo Frigio; Pettorelli, E; Pinna, G; Zunarelli, E; Artioli, F; Bernardini, I; Costa, M; Greco, G; Guerzoni, R; Stucchi, C; Iaccarino, C; Rizzi, R; Zuccoli, G; Api, P; Cartei, F; Fallica, E; Granieri, E; Latini, F; Lelli, G; Monetti, C; Ramponi, V; Saletti, A; Schivalocchi, R; Seraceni, S; Tola, M. R; Urbini, B; Giorgi, C; Montanari, E; Cerasti, D; Crafa, P; Dascola, I; Florindo, I; Mazza, S; Servadei, F; Silini, Em; Torelli, P; Immovilli, P; Morelli, N; Vanzo, C.
File in questo prodotto:
File Dimensione Formato  
npu021.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 171.02 kB
Formato Adobe PDF
171.02 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1073255
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 32
  • ???jsp.display-item.citation.isi??? ND
social impact