Abstract BACKGROUND: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. AIM: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. METHODS: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. RESULTS: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11±3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p=0.007), treatment duration >80% of the scheduled period (p=0.027), and early virological response (p=0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p=0.008). CONCLUSIONS: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.
|Data di pubblicazione:||2014|
|Titolo:||Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C.|
|Autori:||Ponziani, Fr; Viganò, R; Iemmolo, Rm; Donato, Mf; Rendina, M; Toniutto, P; Pasulo, L; Morelli, Mc; Burra, P; Miglioresi, L; Merli, M; Di Paolo, D; Fagiuoli, S; Gasbarrini, A; Pompili, M|
|Digital Object Identifier (DOI):||10.1016/j.dld.2014.01.157. Epub 2014 Mar 11.|
|Appare nelle tipologie:||Articolo su rivista|
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