EnglishAbstract BACKGROUND: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. AIM: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. METHODS: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. RESULTS: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11±3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p=0.007), treatment duration >80% of the scheduled period (p=0.027), and early virological response (p=0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p=0.008). CONCLUSIONS: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.
Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C / Ponziani, Fr; Vigano', Raffaella; Iemmolo, Rm; Donato, Mf; Rendina, Marisa; Toniutto, P; Pasulo, L; Morelli, Mc; Burra, P; Miglioresi, L; Merli, M; Di Paolo, D; Fagiuoli, S; Gasbarrini, A; Pompili, M.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 46(2014), pp. 440-445.
| Data di pubblicazione: | 2014 |
| Titolo: | Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C. |
| Autore/i: | Ponziani, Fr; Vigano', Raffaella; Iemmolo, Rm; Donato, Mf; Rendina, Marisa; Toniutto, P; Pasulo, L; Morelli, Mc; Burra, P; Miglioresi, L; Merli, M; Di Paolo, D; Fagiuoli, S; Gasbarrini, A; Pompili, M. |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.dld.2014.01.157. Epub 2014 Mar 11. |
| Rivista: | |
| Volume: | 46 |
| Pagina iniziale: | 440 |
| Pagina finale: | 445 |
| Codice identificativo ISI: | WOS:000334512500012 |
| Codice identificativo Scopus: | 2-s2.0-84898850237 |
| Codice identificativo Pubmed: | 24635906 |
| Citazione: | Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C / Ponziani, Fr; Vigano', Raffaella; Iemmolo, Rm; Donato, Mf; Rendina, Marisa; Toniutto, P; Pasulo, L; Morelli, Mc; Burra, P; Miglioresi, L; Merli, M; Di Paolo, D; Fagiuoli, S; Gasbarrini, A; Pompili, M.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 46(2014), pp. 440-445. |
| Tipologia | Articolo su rivista |
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