In the present study we have demonstrated that lipopolysaccharide (LPS) acts as an activator in the immunocytes of molluscs Planorbarius corneus, Mytilus edulis, and the insect Leucophaea maderae. This stimulatory effect, demonstrated by cellular conformational changes, is concentration- and time-dependent, and is antagonized by morphine. The inhibitory effect of morphine carl be counteracted by naloxone. Morphine inhibitory action on immunocyte activity is also demonstrated by a decrease in the phagacytic activity. These data suggest that the downregulation of morphine is not limited to vertebrates but is also present in invertebrates.

ANTAGONIZING EFFECT OF MORPHINE ON THE MOBILITY AND PHAGOCYTIC-ACTIVITY OF INVERTEBRATE IMMUNOCYTES / Ottaviani, Enzo; Franchini, Antonella; Sonetti, Dario; Stefano, Gb. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 276:(1995), pp. 35-39.

ANTAGONIZING EFFECT OF MORPHINE ON THE MOBILITY AND PHAGOCYTIC-ACTIVITY OF INVERTEBRATE IMMUNOCYTES

OTTAVIANI, Enzo;FRANCHINI, Antonella;SONETTI, Dario;
1995

Abstract

In the present study we have demonstrated that lipopolysaccharide (LPS) acts as an activator in the immunocytes of molluscs Planorbarius corneus, Mytilus edulis, and the insect Leucophaea maderae. This stimulatory effect, demonstrated by cellular conformational changes, is concentration- and time-dependent, and is antagonized by morphine. The inhibitory effect of morphine carl be counteracted by naloxone. Morphine inhibitory action on immunocyte activity is also demonstrated by a decrease in the phagacytic activity. These data suggest that the downregulation of morphine is not limited to vertebrates but is also present in invertebrates.
1995
276
35
39
ANTAGONIZING EFFECT OF MORPHINE ON THE MOBILITY AND PHAGOCYTIC-ACTIVITY OF INVERTEBRATE IMMUNOCYTES / Ottaviani, Enzo; Franchini, Antonella; Sonetti, Dario; Stefano, Gb. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 276:(1995), pp. 35-39.
Ottaviani, Enzo; Franchini, Antonella; Sonetti, Dario; Stefano, Gb
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/10235
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 21
social impact