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ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF 1-apr-2008 Gambacorti Passerini, Carlo; Gunby, Rosalind Helen; Zambon, Alfonso; Scapozza, Leonardo; Ahmed, Shaheen; Goekjian, Peter G.; Gueyrard, David; Popowycz, Florence; Schneider, Cerric
ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF 1-apr-2008 Gambacorti Passerini, Carlo; Gunby, Rosalind Helen; Zambon, Alfonso; Scapozza, Leonardo; Ahmed, Shaheen; Goekjian, Peter G.; Gueyrard, David; Popowycz, Florence; Schneider, Cerric
Qualitative and quantitative discrimination of fake and true alkene rotation processes in pd(η2-olefin) complexes. A new bimolecular mechanism 1-gen-2009 Lucchini, Vittorio; Borsato, Giuseppe; Canovese, Luciano; Santo, Claudio; Visentin, Fabiano; Zambon, Alfonso
Corrections to pyridoimidazolones as novel potent inhibitors of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) (Journal of Medicinal Chemistry (2009) 52, (2255-2256) DOI: 10.1021/jm801509w) 1-gen-2009 Niculescu-Duvaz, D.; Gaulon, C.; Dijkstra, H. P.; Niculescu-Duvaz, I.; Zambon, A.; Menard, D.; Suijkerbuijk, B. M. J. M.; Nourry, A.; Davies, L.; Manne, H.; Friedlos, F.; Ogilvie, L.; Hedley, D.; Whittaker, S.; Kirk, R.; Gill, A.; Taylor, R. D.; Raynaud, F. I.; Moreno-Farre, J.; Marais, R.; Springer, C. J.
Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF) 1-gen-2009 Niculescu Duvaz, Dan; Gaulon, Catherine; Dijkstra, Harmen P.; Niculescu Duvaz, Ion; Zambon, Alfonso; Menard, Delphine; Suijkerbuijk, Bart M. J. M.; Nourry, Arnaud; Davies, Lawrence; Manne, Helen; Friedlos, Frank; Ogilvie, Lesley; Hedley, Douglas; Whittaker, Steven; Kirk, Ruth; Gill, Adrian; Taylor, Richard D.; Raynaud, Florence I.; Moreno Farre, Javier; Marais, Richard; Springer, Caroline J.
Novel Potent BRAF Inhibitors: Toward 1 nM Compounds through Optimization of the Central Phenyl Ring 1-gen-2009 Menard, Delphine; Niculescu Duvaz, Ion; Dijkstra, Harmen P; I. Niculescu Duvaz, Dan; Suijkerbuijk, Bart M. J. M.; Zambon, Alfonso; Nourry, Arnaud; Roman, Esteban; Davies, Lawrence; Marine, ; Friedlos, Frank; Helen A., And; Kirk, Ruth and; Gill, Adrian; Whittaker, Steven; Taylor, Richard D; Marais, Richard; Springer, Caroline
The discovery of novel, highly potent inhibitors of BRAF 1-gen-2010 Niculescu Duvaz, I.; Menard, D; Niculescu Duvaz, D.; Zambon, Alfonso; Davies, L; Preece, N.; Kirk, R.; Whittaker, S.; Marais, R.; Springer, C.
A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF 1-gen-2010 Whittaker, Steven; Ménard, Delphine; Kirk, Ruth; Ogilvie, Lesley; Hedley, Douglas; Zambon, Alfonso; Lopes, Filipa; Preece, Natasha; Manne, Helen; Rana, Sareena; Lambros, Maryou; Reis Filho, Jorge S.; Marais, Richard; Springer, Caroline J.
Gatekeeper mutations mediate resistance to BRAF-targeted therapies 1-gen-2010 Whittaker, Steven; Kirk, Ruth; Hayward, Robert; Zambon, Alfonso; Viros, Amaya; Cantarino, Neus; Affolter, Annette; Nourry, Arnaud; Niculescu Duvaz, Dan; Springer, Caroline; Marais, Richard
Novel hinge binder improves activity and pharmacokinetic properties of BRAF inhibitors 1-gen-2010 Zambon, Alfonso; Ménard, Delphine; Suijkerbuijk, Bart M. J. M.; Niculescu Duvaz, Ion; Whittaker, Steven; Niculescu Duvaz, Dan; Nourry, Arnaud; Davies, Lawrence; Manne, Helen A.; Lopes, Filipa; Preece, Natasha; Hedley, Douglas; Ogilvie, Lesley M.; Kirk, Ruth; Marais, Richard; Springer, Caroline J.
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds 1-gen-2010 Niculescu Duvaz, Dan; Niculescu Duvaz, Ion; Suijkerbuijk, Bart M. J. M.; Ménard, Delphine; Zambon, Alfonso; Nourry, Arnaud; Davies, Lawrence; Manne, Helen A.; Friedlos, Frank; Ogilvie, Lesley; Hedley, Douglas; Takle, Andrew K.; Wilson, David M.; Pons, Jean Francois; Coulter, Tom; Kirk, Ruth; Cantarino, Neus; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors 1-gen-2010 Mologni, Luca; Rostagno, Roberta; Brussolo, Stefania; Knowles, Phillip P.; Kjaer, Svend; Murray Rust, Judith; Rosso, Enrico; Zambon, Alfonso; Scapozza, Leonardo; Mcdonald, Neil Q.; Lucchini, Vittorio; Gambacorti Passerini, Carlo
BRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring 1-gen-2010 Nourry, Arnaud; Zambon, Alfonso; Davies, Lawrence; Niculescu Duvaz, Ion; Dijkstra, Harmen P.; Ménard, Delphine; Gaulon, Catherine; Niculescu Duvaz, Dan; Suijkerbuijk, Bart M. J. M.; Manne, Frank Friedlos Helen A.; Kirk, Ruth; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): Increasing cellular potency through optimization of a distal heteroaromatic group 1-gen-2010 Suijkerbuijk, Bart M. J. M.; Niculescu Duvaz, Ion; Gaulon, Catherine; Dijkstra, Harmen P.; Niculescu Duvaz, Dan; Ménard, Delphine; Zambon, Alfonso; Nourry, Arnaud; Davies, Lawrence; Manne, Helen A.; Friedlos, Frank; Ogilvie, Lesley M.; Hedley, Douglas; Lopes, Filipa; Preece, Natasha P. U.; Moreno Farre, Javier; Raynaud, Florence I.; Kirk, Ruth; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
1-(5-tert-butyl-2-phenyl-2H-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-B]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy 27-gen-2011 Springer, Caroline; Niculescu-Duvaz, Ion; Marais, Richard; Niculescu-Duvaz, Dan; Zambon, Alfonso; Menard, Delphine
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors 1-gen-2012 Su, F; Viros, A; Milagre, C; Trunzer, K; Bollag, G; Spleiss, O; Reis, Js; Kong, Xj; Koya, Rc; Flaherty, Kt; Chapman, Pb; Kim, Mj; Hayward, R; Martin, M; Yang, H; Wang, Qq; Hilton, H; Hang, Js; Noe, J; Lambros, M; Geyer, F; Dhomen, N; Niculescu Duvaz, I; Zambon, Alfonso; Niculescu Duvaz, D; Preece, N; Robert, L; Otte, Nj; Mok, S; Kee, D; Ma, Y; Zhang, C; Habets, G; Burton, Ea; Wong, B; Nguyen, H; Kockx, M; Andries, L; Lestini, B; Nolop, Kb; Lee, Rj; Joe, Ak; Troy, Jl; Gonzalez, R; Hutson, Te; Puzanov, I; Chmielowski, B; Springer, Cj; Mcarthur, Ga; Sosman, Ja; Lo, Rs; Ribas, A; Marais, R.
Paradoxical activation of the MEK/ERK pathway promotes melanoma invasion and metastasis 1-gen-2012 Sanchez Laorden, B.; Viros, A.; Girotti, R.; Pedersen, M.; Zambon, Alfonso; Niculescu Duvaz, D.; Springer, C; Marais, R.
Small molecule inhibitors of BRAF in clinical trials 1-gen-2012 Zambon, Alfonso; Niculescu Duvaz, Ion; Niculescu Duvaz, Dan; Marais, Richard; Springer, Caroline J.
Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma 1-gen-2013 Girotti, Maria R.; Pedersen, Malin; Sanchez Laorden, Berta; Viros, Amaya; Turajlic, Samra; Niculescu Duvaz, Dan; Zambon, Alfonso; Sinclair, John; Hayes, Andrew; Gore, Martin; Lorigan, Paul; Springer, Caroline; Larkin, James; Jorgensen, Claus; Marais, Richard
Topical 5-Fluorouracil Elicits Regressions of BRAF Inhibitor–Induced Cutaneous Squamous Cell Carcinoma 1-gen-2013 Viros, Amaya; Hayward, Robert; Martin, Matthew; Yashar, Sharona; Yu, Clarissa C.; Sanchez Laorden, Berta; Zambon, Alfonso; Niculescu Duvaz, Dan; Springer, Caroline; Lo, Roger S; Marais, Richard
Mostrati risultati da 21 a 40 di 81
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